Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. Tetrodotoxin Discodermolide Azaspiracid-1 Thiostrepton Pentacycloanammoxic Acid Methyl Ester Littoralisone, Oseltamivir, and Hirsutellone B Rubicordifolin and Rubicolin B Cyanthiwigins U and F Strephacidin B Abyssomicin C and atrop-Abyssomicin C Tetracycline Bisanthraquinone Natural Products Garsubellin A Welwitindolinone A Isonitrile Azadirachtin Iejimalide B Kedarcidin Chromophore and Maduropeptin Chromophore Biyouyanagin A Resveratrol-Based Natural Products Chlorosulfolipid Sporolide B 11,11'-Dideoxyverticillin A Vannusal B Haplophytine Palau'amine