The Sign of Four is one of Sherlock Holmes's great adventures, a tale of 'an injured lady, half a million in treasure, a black cannibal, and a wooden-legged ruffian' A dense yellow miasma swirls in the streets of London as Sherlock Holmes and Dr Watson accompany a beautiful young woman to a sinister assignation. For Mary Marston has received several large pearls - one a year for the last six years - and now a mystery letter telling her she is a wronged woman.