Provides a critical summary of research approaches to the epidemiological study of workplace hazards. This second edition provides discussions of methods such as case-cohort and case-crossover designs and statistical analysis of repeated measures data, a chapter on occupational health surveillance, and examples involving chronic health outcomes. Introduction 3(14) Historical Background 4(4) The Scope of Occupational Epidemiology 8(9) Characterizing the Workplace Environment 17(42) General Concepts of Exposure and Dose 18(3) Approaches to Exposure Assessment 21(22) Reliability and Validity of Exposure Assessment 43(6) Combining Exposure Data from Multiple Sources 49(10) Overview of Study Designs 59(24) Case Series 59(2) Cohort Studies 61(5) Case-Control Studies 66(4) Proportionate Mortality Studies 70(2) Cross-sectional Studies 72(1) Connections between Study Designs 73(10) Precision and Validity in Study Design 83(40) Precision 83(6) Validity 89(23) Effect Modification and Estimation of Joint Effects 112(11) Cohort Studies 123(56) Basic Cohort Design 123(13) Methods of Data Analysis 136(11) Strategies of Analysis 147(26) Planning a Cohort Study 173(6) Case-Control Studies 179(32) Basic Study Design 180(1) Selection of Cases 181(2) Selection of Controls 183(15) Exposure Data 198(1) Data Analysis 199(12) Cross-sectional and Repeated Measures Studies 211(36) Study Design Features 211(7) Sources of Health and Exposure Data 218(1) Subject Selection Options 219(7) Methods of Data Analysis 226(10) Sources of Bias in Cross-sectional Studies 236(5) Planning Cross-sectional and Repeated Measures Studies 241(6) Occupational Health Surveillance 247(16) Defining Surveillance 248(1) Selecting Health Outcomes for Surveillance 248(1) Surveillance Study Designs 249(1) Surveillance in Defined Occupational Cohorts 249(3) Surveillance in the General Population 252(11) Advanced Statistical Analysis 263(32) Continuous Outcome Data 264(6) Dichotomous Outcome Data 270(10) Model Specification 280(15) Exposure and Dose Modeling 295(36) The Starting Point: The Exposure Profile 296(1) Summary Measures of Exposure 297(3) Understanding the Exposure--Dose Relation 300(8) Is Dose the Right Metric? 308(2) The Dosimetric Model 310(8) Incorporating Inter-individual Variability into Dose Metrics 318(1) Exposure Weighting 319(2) Induction Time Analysis 321(2) Multistage Cancer Model 323(2) Choosing the Best Measure of Exposure or Dose 325(1) Strengths and Limitations of Dose Modeling 326(5) Special Applications of Occupational Epidemiology 331(28) Meta-Analysis 331(12) Data Pooling 343(3) Risk Assessment 346(13) Index 359