Equilibria and Kinetics of Biological Macromolecules provides readers with an understanding of the biophysics of macromolecules. Equilibria and Kinetics of Biological Macromolecules provides readers with an understanding of the biophysics of macromolecules. Part 1. Basic principles Chapter 1. Thermodynamics Chapter 2. Four basic quantum mechanical models of nuclear & electronic motion: a synopsis. Chapter 3. Molecular structure and interactions Chapter 4. Water and the hydrophobic effect Part 2. Statistical mechanics: The molecular basis of thermodynamics Chapter 5. The molecular partition function Chapter 6. System ensembles and partition functions Chapter 7. Sampling molecular systems with simulations Part 3. Binding to macromolecules Chapter 8. Binding equilibria Chapter 9. Thermodynamics of molecular interactions Chapter 10. Elements of statistical mechanics of liquids and solutions Chapter 11. Analysis of binding equilibria in terms of partition functions Chapter 12. Coupled equilibria Chapter 13. Allosteric function Chapter 14. Charged groups: Binding of hydrogen ions, solvation and charge-charge interactions Part 4. Conformational stability and conformation change Chapter 15. Some elements of polymer physics Chapter 16. Helix-coil equilibria Chapter 17. Protein unfolding equilibria Chapter 18. Elasticity of biological materials Part 5. Kinetics and irreversible processes Chapter 19. Kinetics Chapter 20. Kinetics of protein folding Chapter 21. Irreversible and stochastic processes Appendices Appendix 1: Probability Appendix 2: Random walk and central limit theorem Appendix 3: The grand partition function: derivation and relation to other types of partition functions Appendix 4: Methods to compute a PMF Appendix 5: Theory of the helix-coil transition Appendix 6: Laplace transform Appendix 7: Poisson equation Appendix 8: Defining molecular boundaries Appendix 9: Equations Appendix 10: Useful facts