Voet's Principles of Biochemistry, Global Edition addresses the enormous advances in biochemistry, particularly in the areas of structural biology and bioinformatics. It provides a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future. PART I INTRODUCTION 1 Life, Cell and Thermodynamics 1 2 Physical and Chemical Properties of Water 23 PART II BIOMOLECULES 3 Overview of DNA Structure, Function, and Engineering 42 4 Amino Acids 80 5 Polypeptide Analysis, Sequencing and Evolution 97 6 Proteins: Structure and Folding 131 7 Physiological Activities of Proteins 180 8 Saccharide Chemistry 221 9 Lipids, Bilayer and Membranes 245 10 Passive and Active Transport 293 PART III ENZYMES 11 Mechanisms of Enzyme Action 322 12 Properties of Enzymes 361 13 Hormones and Signal Transduction 402 PART IV METABOLISM 14 Bioenergetics 442 15 Glycolysis and the Pentose Phosphate Pathway 478 16 Additional Pathways in Carbohydrate Metabolism 523 17 The Citric Acid Cycle 558 18 Mitochondrial ATP Synthesis 588 19 Photosynthesis: Can be found at www.wiley.com/college/voet 20 Synthesis and Degradation of lipids 664 21 Synthesis and Degradation of Amino Acids 718 22 Regulation of Fuel Metabolism 773 PART V GENE EXPRESSION AND REPLICATION 23 Nucleotide Synthesis and Degradation 802 24 DNA structure and Interactions with Proteins 831 25 DNA Synthesis and Repair 879 26 RNA Metabolism 938 27 The Genetic Code and Translation 982 28 Gene Expression in Prokaryotes and Eukaryotes 1033 Solutions: Can be found at www.wiley.com/college/voet Glossary G-1 Index I-1