Substance Use and Misuse: A Helper's Guide to Neuroscience-Based Treatment equips helping professionals with the knowledge needed to work effectively with individuals who misuse substances and also underscores the skills and attitudes necessary to be successful with clients struggling with misuse. The book uses the lens of neuroscience to focus the art of helping, providing helping professionals with rich research, practical examples, and inclusion of material on the interplay of the brain, the nervous system, and substance use. Opening chapters provide readers with essential historical, social, and political context, a review of ethics and culture in substance use and treatment, and critical information about neuroscience essentials and how drugs affect the brain. Additional chapters cover the dimensions of substance misuse, the neuroscience of helping, and the processes of screening, assessment, diagnosis, and referral. Readers learn about relevant theories and models of substance misuse, treatment approaches, motivational interviewing, and brain-based mindful interventions. Chapters cover co-occurring disorders, treatment beyond relapse prevention and termination, treating marginalized and minoritized populations, and more. Opening questions, real-world vignettes, culture and ethics sections, and practical application suggestions enrich the reading and learning experience. Featuring a unique multicultural orientation and a highly contemporary focus on neuroscience rather than addiction, Substance Use and Misuse is well suited for undergraduate and graduate courses with focus on the topic.