Arterial disease and inflammation are fundamental causes of many medical conditions. Recently, there have been several major advances in our understanding of the causes of diseases affecting the heart, lungs, kidneys, skin and blood vessels. The role of endothelium derived growth factors, nitric oxide and other messengers in vascular disease has been more clearly defined. New treatments targeting these molecular disorders are being used with beneficial effects. Further progress depends on a combined approach embracing basic and clinical research so that treatments of common, important diseases can be designed intelligently and logically. "Vascular Complications in Human Disease" presents our understanding of vascular disease, in reviews of the main strands of basic and clinical research written by leading international experts. It also identifies routes for further fruitful research and development. This concise and carefully edited book, avoiding repetition, includes the full spectrum of basic research which is not covered in other textbooks. TOC:Therapy for Pulmonary Vascular Disease.- Nitric Oxide Axis in Cardio-Pulmonary Disease.- Endothelin Signalling in the Cardiomyocyte.- TGF-beta/BMP Signalling in Pulmonary Vascular Disease.- The Endothelin System in Chronic Kidney Disease.- Endothelial Activation in Inflammation.- Pathogenic Mediators of Vessel Sclerosis.- Control of Interstitial Fluid Homeostasis.- Vascular Complications of Systemic Sclerosis.- Therapeutic Options for Preventing Transplant-Related Progressive Renal and Vascular Injury.- Current State of Medical Therapies for Peripheral Vascular Disease.- Advantages of Harvesting the Saphenous Vein for Coronary Artery Bypass Surgery Using the "No- Touch" Technique.- Towards the Prevention of Vein Graft Failure.- Statins and Cholesterol.- Endothelin-1 Promoting Actions in the Growth and Angiogenesis of Solid Cancers.- Gene Therapy for Apolipoprotein A-I and HDL - The Ultimate Treatment for Atherosclerosis?- Ets Family of Transcription Factors and Vascular System.- The Aortic Valve: From Function to Tissue Engineering. Arterial disease and inflammation are fundamental causes of many medical conditions. Recently, there have been several major advances in our understanding of the causes of diseases affecting the heart, lungs, kidneys, skin and blood vessels. The role of endothelium derived growth factors, nitric oxide and other messengers in vascular disease has been more clearly defined. New treatments targeting these molecular disorders are being used with beneficial effects. Further progress depends on a combined approach embracing basic and clinical research so that treatments of common, important diseases can be designed intelligently and logically. "Vascular Complications in Human Disease" presents our understanding of vascular disease, in reviews of the main strands of basic and clinical research written by leading international experts. It also identifies routes for further fruitful research and development. This concise and carefully edited book, avoiding repetition, includes the full spectrum of basic research which is not covered in other textbooks. Foreword v Dame Carol Black Lewis J. Rubin Jeremy D. Pearson Preface vii Section One Treatments for Pulmonary Vascular Disease Therapy for Pulmonary Vascular Disease: Past, Present, and Future 3(6) Lewis J. Rubin Nitric Oxide Axis in Cardiopulmonary Disease 9(5) Patrick Vallance Endothelin Signaling in the Cardiomyocyte 14(32) Peter H. Sugden Angela Clerk TGF-?/BMP Signaling in Pulmonary Vascular Disease 46(17) Rachel J. Davies Nicholas W. Morrell Section Two Model Systems Endothelin System in Chronic Kidney Disease 63(14) Neeraj Dhaun David J. Webb Jane Goddard Endothelial Activation in Inflammation: Lessons Learned from E-Selectin 77(17) Dorian O. Haskard Pathogenic Mediators of Vessel Sclerosis: Regulation of Vascular Smooth Muscle Cell Proliferation by Growth Factors, the Extracellular Matrix, and the Endothelium 94(11) Mark Bond Yih-Jer Wu Graciela Sala-Newby Andrew C. Newby Control of Interstitial Fluid Homeostasis: Roles of Growth Factors and Integrins 105(14) Kristofer Rubin Asa Liden Tijs van Wieringen Rolf K. Reed Section Three Vascular Complications Vascular Complications of Systemic Sclerosis: A Molecular Perspective 119(9) Daryll M. Baker Christopher Denton Therapeutic Options for Preventing Transplant-Related Progressive Renal and Vascular Injury 128(11) Susanna Tomasoni Ariela Benigni Section Four Surgical Approaches Current State of Medical Therapies for Peripheral Vascular Disease 139(11) Janice C.S. Tsui Daryll M. Baker Advantages of Harvesting the Saphenous Vein for Coronary Artery Bypass Surgery Using the ``No-Touch'' Technique 150(8) Domingos Savio Ramos de Souza Bruno Botelho Pinheiro Toward the Prevention of Vein Graft Failure 158(21) Jamie Y. Jeremy Sarah J. George Nilima Shukla Marcella Wyatt Jonathon Bloor Andrew C. Newby Gianni D. Angelini Section Five Genetics, Gene Therapy, and Tissue Engineering Statins and Cholesterol: How Low Can You Go? 179(8) Dimitri P. Mikhailidis Endothelin-1-Promoting Actions in the Growth and Angiogenesis of Solid Cancers 187(10) Marilena Loizidou Gene Therapy for Apolipoprotein A-I and HDL---The Ultimate Treatment for Atherosclerosis 197(16) Petra Disterer Eyman Osman James S. Owen ETS Family of Transcription Factors and the Vascular System 213(16) Masaomi Yamasaki Aortic Valve: From Function to Tissue Engineering 229(12) Adrian H. Chester Najma Latif Magdi H. Yacoub Patricia M. Taylor Index 241