The first book to focus on pediatric oncology for pharmacists now reaches its second edition. This edition includes updates featuring new drugs, approaches and techniques, as well as new chapters such as “Post-Pandemic Pediatric Oncology Pharmacy,” “Cardiotoxicity in Pediatric Oncohematology” and “Pediatric Oncological and Hematological Treatment of Children Undergoing Hormone Therapy for Gender Dysphoria.” Publications addressing chemotherapy in children remain scarce, and pharmacists often struggle to find the information they need because it is spread across numerous articles, unpublished, or literature aimed at other professionals. Pediatric Oncologic Pharmacy is a field in which increasingly specialized knowledge is required in daily practice. Oncopediatric books rarely cover topics unique to pharmacy—such as the handling of cytotoxic drugs for children, analysis of oncopediatric prescriptions, clinical pharmacy in pediatric oncology, pharmaceutical care in the pediatric oncology setting and other subjects of exclusive relevance to these professionals, but essential for high-quality therapy. Addressing this need, the purpose of this second edition is to serve as an updated guideline encompassing all subjects that pediatric oncology pharmacists must master to work effectively in this field. It is an essential guide for pediatric oncology pharmacists, clinical pharmacists, pharmaceutical residents involved in pediatric drug therapy, and pharmaceutical researchers. This handbook supports daily practice and serves as an essential resource for pediatric oncology and hematology institutions.