This advanced textbook is tailored for an introductory course in Systems Biology and is well-suited for biologists as well as engineers and computer scientists. It comes with student-friendly reading lists and a companion website featuring a short exam prep version of the book and educational modeling programs. This advanced textbook is tailored for an introductory course in Systems Biology and is well-suited for biologists as well as engineers and computer scientists. It comes with student-friendly reading lists and a companion website featuring a short exam prep version of the book and educational modeling programs. INTRODUCTION TO SYSTEMS BIOLOGY Introduction Modeling of Biochemical Systems Specific Biochemical Systems Model Fitting Analysis of High-throughput Data Gene Expression Models Stochastic Systems and Variability Network Structures, Dynamics, and Function Optimality and Evolution BIOLOGICAL AND MATHEMATICAL FUNDAMENTALS AND METHODS Cell Biology Experimental Techniques in Molecular Biology Mathematics Statistics Stochastic Processes Linear Control Systems Databases Modeling Tools