Computational 3D Modeling of Hemodynamics in the Circle of Willis
A thesis presented for the degree of Doctor ofPhilosophy in Mechanical Engineering at the University ofCanterbury, Christchurch, New Zealand
Omschrijving
This book is the culmination of approximately fouryears of study obtaining my PhD in mechanical engineering, modelingblood flow in the arteries of the human brain. Coming from anengineering background I found that I had very little knowledgeof human anatomy, physiology, or medical imaging techniques.Furthermore, it seemed reasonable that there would not be many people possessing a deep knowledge of these fields, and themore engineering related fields of computational fluiddynamics and mathematical modeling. As a result this book containsreasonably detailed background information on all of the aforementioned fields, inorder to provide the novice with a well balanced understanding of allaspects of this modeling challenge. The actual body of work involves the development of techniques to segment out the cerebralarteries from magnetic resonance imaging scans, and create the computational meshes. In addition there is thedevelopment of a mathematical model of the physiological controlsystem known as the cerebral autoregulation mechanism, and the couplingof this control system to the computational fluid dynamics simulations.
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