Equine Metabolic Syndrome. (Patho-)physiological variations in insulin sensitivity, glucose homeostasis and lipid metabolism in lean and obese horses

(Patho-)physiological variations in insulin sensitivity, glucose homeostasis and lipid metabolism in lean and obese horses

Warnken, Tobias - Equine Metabolic Syndrome. (Patho-)physiological variations in insulin sensitivity, glucose homeostasis and lipid metabolism in lean and obese horses

Omschrijving

Variations in insulin regulation reflect either as tissue insulin resistance or insulin dysregulation result in moderate to severe hyperinsulinemia in horses and ponies suffering from the Equine Metabolic Syndrome (EMS). Several pathomechanisms provoking equine insulin resistance have been suggested, but insulin signaling in healthy horses has not been studied in detail so far. Thus the objective of this PhD project was to investigate equine insulin sensitivity, glucose homeostasis and lipid metabolism by combining examinations of insulin signaling on a protein level in different main metabolic tissues and analyses of dynamic hormone and metabolite changes during acute stimulations by either oral glucose application or IV insulin and glucose injection. Furthermore, systemic markers of insulin resistance were analyzed by an innovative targeted metabolomics approach to provide better understanding of potential pathomechanisms involved in impaired insulin regulation in horses. In conclusion, equine-specific insulin signaling, the marginal relationship of insulin sensitivity to obesity and strong associations of high plasma insulin concentration to cellular oxidative stress depicted not only a special physiological condition but also indicate novel pathophysiological conditions underlying EMS.

In de winkelwagen 17 werkdagen Wenslijst Stel een vraag

Gratis verzending vanaf
€ 19,95 binnen Nederland

Schrijver: Warnken, Tobias
Titel: Equine Metabolic Syndrome. (Patho-)physiological variations in insulin sensitivity, glucose homeostasis and lipid metabolism in lean and obese horses
Uitgever: Cuvillier

Jaar: 2018
Taal: Engels
Pagina's: 118

EAN: 9783736998063
Bindwijze: Paperback

U ontvangt bij ons altijd de laatste druk!

Equine Metabolic Syndrome. (Patho-)physiological variations in insulin sensitivity, glucose homeostasis and lipid metabolism in lean and obese horses

(Patho-)physiological variations in insulin sensitivity, glucose homeostasis and lipid metabolism in lean and obese horses

Omschrijving

Rubrieken

Stel een vraag