A Synthesis of Baconipyrone through New Catalytic Asymmetric Methods
The Importance of N-Heterocyclic Carbene Ligands in Asymmetric Olefin Metathesis and Asymmetric Allylic Alkylation
Omschrijving
The societal need for optically enriched molecules
(e.g. in pharmaceuticals or new materials) continues
to drive the development of new synthetic methods for
enantioselective synthesis. This work discusses the
development of new chiral catalysts and ligands for
two important synthetic synthetic methods:
Ru-catalyzed asymmetric olefin metathesis, and
Cu-catalyzed asymmetric allylic alkylation. These
methods were applied to a total synthesis of the
marine natural product baconipyrone C. Other
highlights include the development of a mild new
method for the synthesis of the gamma-pyrone motif
and the use of tethered ring-closing olefin
metathesis as an alternative to olefin
cross-metathesis. Practitioners of organic synthesis
should find this book particularly useful for the new
carbon-carbon bond-forming methods presented, as well
as the novel synthetic strategies.
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