Cellular Mechanisms of Hippocampal LTP and LTD Learning and Memory
Learning and Memory
Omschrijving
Processes of functional plasticity, i.e. long-
lasting changes of the strength of synaptic
connectivity in response to relative short-lasting
afferent stimulation, are the most likely mechanisms
underlying memory storage in the adult brain. The
best studied models of functional plasticity are
long-term potentiation (LTP) and long-term
depression (LTD). Rolipram, a specific type IV-
specific cAMP phosphodiesterase (PDE) inhibitor, was
used in my initial studies to investigate its effect
on late plastic events during functional CA1
plasticity in rat hippocampal slices in vitro. In
the later part of my studies, I was interested to
investigate the question of what exactly is the
putative nature of the synaptic tag. Are there
specific ¿tags¿ for LTP and LTD?
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