Gene Regulation of Gene Expression in Human Genome
Gene Regulation in Eukaryotic cell
Omschrijving
Gene Sequence of DNA or RNA which codes for molecule that has function. Product include: SiRNA, rRNA, miRNA, tRNA, mRNA. Gene Expression, information from a Gene is used in the synthesis of functional gene products. Molecular Levels Level one:1-DNA, 2-TranscriptionLevel Two - 1-RNA, 2-Translation, 3-RNACommon transcription factor motifs¿ Zinc finger ¿ Helix-loop-helix (HLH) ¿ Leucine zipper (LZ) ¿ HMG box (high mobility group ) ¿ Shared feature ¿ Structurally stable framework ¿ Specific DNA recognizing sequences are correctly positioned, Repression of Transcription Cells also possess negative regulatory elementsMechanisms: ¿ Binding to promoter elements. ¿ Blocking assembly of the preinitiation complex. ¿ Inhibiting binding or functioning of transcriptional activators. ¿ Modifying DNA and its interaction with nucleosomes. Some transcription factors activate some genes and repress others.
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